Department of Cardiology, Inselspital, University of Bern, Bern, Switzerland. Electronic address: thomas.pilgrim@insel.ch. Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. Institute of Social and Preventive Medicine, Inselspital, University of Bern, Bern, Switzerland; Clinical Trials Unit, Inselspital, University of Bern, Bern, Switzerland. Department of Cardiology, Geneva University Hospital, Geneva, Switzerland. Department of Cardiology, Triemlispital, Zurich, Switzerland. Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland. Department of Cardiology, Kantonsspital Aarau, Aarau, Switzerland. Department of Cardiology, Inselspital, University of Bern, Bern, Switzerland. Department of Cardiology, University and Hospital Fribourg, Fribourg, Switzerland. Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland. Department of Cardiology, University Hospital Basel, Basel, Switzerland. Department of Cardiology, Luzerner Kantonsspital, Luzern, Switzerland. Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.